• How NAD Precursors Work in the Body or what do I need to understand before taking a NAD supplement

    Generated by ChatGPT (GPT-5 Thinking mini, OpenAI). Answer obtained August 10, 2025. Note: AI-generated content may contain inaccuracies; consult primary literature for clinical decisions.

    Step 1 — Ingestion

    • You swallow NR, NMN, or niacinamide.

    • NAD⁺ itself is mostly broken down in the gut into smaller units before absorption.

    Step 2 — Absorption

    • NR: Taken up in the small intestine by nucleoside transporters.

    • NMN: Likely broken down into NR before uptake in humans (still debated), though some evidence suggests a specific transporter exists in mice.

    • Niacinamide: Readily absorbed via facilitated diffusion.

    Step 3 — First-pass conversion

    • In intestinal cells and liver, precursors enter the NAD salvage pathway:

    • NR → NMN → NAD⁺

    • NAM → NMN → NAD⁺

    • Enzymes: NRK (nicotinamide riboside kinase) and NMNAT (nicotinamide mononucleotide adenylyltransferase) are key rate-limiting steps.

    Step 4 — Distribution

    • NAD⁺ made in the liver is not directly shipped out — instead, NAD precursors (like NAM) circulate and are taken up by other tissues to make their own NAD⁺.

    Step 5 — Regulation & limits

    • If intake is too high, excess NAM accumulates. This inhibits sirtuins and PARPs, counteracting benefits.

    • Enzymes like CD38 constantly break down NAD⁺ — higher with age and inflammation, meaning older adults may “burn through” NAD⁺ faster.

    • Cells balance NAD⁺ pools across the nucleus, cytosol, and mitochondria separately — boosting blood NAD⁺ doesn’t guarantee a big mitochondrial bump.

    Key takeaway for dosage:

    • There’s a ceiling: above a certain point, enzymes and feedback loops turn extra NAD precursors into waste products or inhibitors.

    • For most healthy adults in studies, 300–500 mg/day NR or NMN moves NAD⁺ significantly; beyond 1 g/day, gains flatten and side effects (like flushing or digestive upset) can increase.

    Prompt:

    What do we know about the biology of NAD taken as a supplement.  By biology is meant does oral ingestion really result in improving what we know the molecule does.  Also biology is replete with examples of just the right amount being critical and that suggests dosage matters

    Response

    NAD biology is tricky, because the molecule is central to metabolism but also because taking it as a supplement doesn’t work as cleanly as people often assume. Let’s break it down carefully.

    1. What NAD does in the body

    • Core role: NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme that shuttles electrons in redox reactions — it’s essential for energy production (glycolysis, TCA cycle, oxidative phosphorylation).

    • Other roles: It’s also a substrate for enzymes that regulate DNA repair (PARPs), gene expression (sirtuins), and cell signaling (CD38).

    • Decline with age: Tissue NAD⁺ levels tend to drop with age and in certain diseases, which has spurred interest in supplements.

    2. The problem with taking NAD⁺ directly

    • Poor absorption: NAD⁺ itself is too large and charged to cross cell membranes efficiently and is rapidly broken down in the gut.

    • Blood stability: Even if some NAD⁺ gets absorbed, blood enzymes degrade it quickly into smaller molecules before it reaches cells intact.

    3. Why precursors are used instead

    Most supplements aren’t pure NAD⁺ — they’re precursors that cells can convert into NAD⁺:

    • Niacin (vitamin B3) — classic form, raises NAD⁺ but can cause flushing.

    • Nicotinamide (NAM) — raises NAD⁺ but in high doses can inhibit sirtuins (feedback inhibition).

    • Nicotinamide riboside (NR) — marketed for NAD⁺ boosting; shown to raise NAD⁺ in blood and some tissues in humans.

    • Nicotinamide mononucleotide (NMN) — similar to NR, but one step closer to NAD⁺ in the biosynthetic pathway. Absorption route in humans is still debated.

    4. What the evidence says about oral supplementation

    • Human trials: Small clinical studies show NR and NMN can raise blood NAD⁺ by ~20–60% within days to weeks.

    • Tissue effects: Less clear — increases in muscle NAD⁺ are modest in healthy young adults, but more noticeable in older adults or those with metabolic issues.

    • Functional benefits: Early human data suggest possible improvements in some measures (insulin sensitivity, vascular function), but effects are modest and not always reproducible.

    • Animal vs human: Mice show bigger and more consistent benefits (lifespan extension, improved mitochondrial function) than humans so far.

    5. The dosage question — “just right” matters

    Biology often follows a U-shaped curve:

    • Too little NAD⁺ → impaired energy metabolism, DNA repair, resilience to stress.

    • Too much NAD⁺ → potential issues:

    • Sirtuin/PARP overactivation (could affect cell cycle or stress response).

    • NAM accumulation from breakdown, which at high levels inhibits sirtuins.

    • Possible support for growth of some cancer cells (since cancer often thrives on robust NAD⁺ metabolism).

    • Most human trials use 250–1000 mg/day of NR or NMN and report it as safe for months to years — but long-term effects beyond that aren’t known.

    6. Key uncertainties

    • Optimal target NAD⁺ level for different ages and conditions isn’t known.

    • Which tissues benefit most from supplementation — blood NAD⁺ isn’t always a good proxy for brain, heart, or muscle.

    • Whether long-term high-dose use has subtle downsides, especially in those without NAD⁺ deficiency.

    Bottom line

    • Oral NAD⁺ itself doesn’t survive digestion well; precursors like NR and NMN do raise blood NAD⁺ in humans.

    • There’s good biochemical evidence they work in principle, but the translation into large, lasting health gains in humans is still tentative.

    • Dose likely matters a lot — both too little and too much could be counterproductive.

    At present, the strongest case for supplementation is in older adults or people with certain metabolic or mitochondrial disorders, not necessarily healthy young individuals.

  • How to resist the destruction of the nation

    from DR. TIMOTHY D. SNYDER, Richard C. Levin
    Professor of History at Yale University:
    “THE LOGIC OF DESTRUCTION – And how to resist it”

    https://www.facebook.com/share/p/15358k2oCT/?mibextid=wwXIfr

  • Education not restricted by religion is vital for science and economy in the long run

    Education is how China will be first world in 100 years and the west becomes the third world

    Cue: Good quality science educated people that is made possible by a system not encumbered by Religion which opposes ability to think for yourself.

    The real reason why the west will become a third world and China the first world – Education that is focused.

    For China this is cultural. The Confucian ideal is the high quality education required to be public servants to the king who then has the best quality of advisers to rule and build society.

    My opinion is that besides this you need the ability to think for yourself. The west had the monopoly on “think for yourself” which means shed your biases and apply that in science.

    A democracy that separates church from state is critical to build the next generation that is creative and productive. Religion in my opinion, regardless of the variety that opposes the secular ideal is detrimental to science and human expression.

  • Applied NonDualism

    Perplexity is an intelligent integrator of different LLMs.

    I asked it to apply Western logic to the concept of non-dualism (Advaita in Sanskrit) and the idea of Mithya in Sanskrit

    Response:

    To apply Western logic to the concept of mithyā in Advaita Vedanta, we can analyze the philosophical framework of mithyā using principles such as categorical reasoning, logical consistency, and ontological classification. Here’s how this can be done:


    1. The Ontological Status of Mithyā

    In Advaita, mithyā is defined as that which is neither absolutely real (satya) nor absolutely unreal (asatya). Using Western logic, we can frame this as a tertium quid—a third category of existence that lies between two extremes. This challenges the classical Aristotelian principle of the excluded middle, which posits that something must either exist or not exist (A or ¬A). Mithyā introduces a nuanced middle ground:

    • Logical Formulation:
      If “real” (satya) is defined as unchanging and independent (e.g., Brahman), and “unreal” (asatya) is defined as non-existent (e.g., a square circle), then mithyā can be expressed as:
      $$
      x \neq \text{satya}, \quad x \neq \text{asatya}, \quad \therefore x = \text{mithyā}.
      $$
      Mithyā is thus conditionally real—it exists only as long as ignorance (avidyā) persists.

    2. Superimposition and Epistemic Dependence

    Advaita explains mithyā through the process of adhyāsa (superimposition), where something is mistakenly perceived due to ignorance. For example, mistaking a rope for a snake. In Western logic, this can be analyzed using the concept of epistemic dependence:

    • The snake appears real only because of ignorance about the rope. This aligns with the idea that mithyā has no independent existence but derives its apparent reality from Brahman.
    • Logical expression:
      Let $$ R = \text{rope} $$, $$ S = \text{snake} $$, and $$ I = \text{ignorance} $$.
      The perception of $$ S $$ depends on $$ I $$. When $$ I = 0 $$ (ignorance removed), $$ S = 0 $$. Thus:
      $$
      S = f(I, R), \quad f(I=0, R) = R.
      $$

    This logical dependency shows that mithyā exists only in relation to ignorance.


    3. Mithyā and Relational Reality

    Western metaphysics often distinguishes between absolute reality (substance) and relational reality (phenomena). Mithyā can be understood as relational reality, akin to Kant’s notion of phenomena versus noumena:

    • In Kantian terms, phenomena (the world as it appears) are conditioned by space, time, and causality—categories imposed by the mind. Similarly, mithyā is conditioned by avidyā and māyā.
    • Logical analogy:
      If $$ P = \text{phenomena}, N = \text{noumena}, M = \text{mithyā}, B = \text{Brahman} $$:
      Just as $$ P/N = M/B $$, phenomena are to noumena what mithyā is to Brahman.

    This analogy illustrates how mithyā is experientially real but ontologically dependent.


    4. Mithyā as Contingent Truth

    In Western logic, contingent truths are those that depend on specific conditions or contexts. Mithyā fits this definition because it exists only within the framework of empirical experience (vyavahārika):

    • Logical statement:
      If $$ T_c = \text{contingent truth}, T_a = \text{absolute truth} $$, then:
      Mithyā belongs to $$ T_c $$, while Brahman belongs to $$ T_a $$.

    This categorization aligns with Advaita’s distinction between vyavahārika satya (empirical truth) and pāramārthika satya (absolute truth).


    5. Resolution Through Non-Duality

    Finally, Western logic can analyze how mithyā resolves into non-duality upon realization of Brahman. This is akin to resolving an apparent contradiction:

    • Contradiction: The world appears real but is declared unreal in Advaita.
    • Resolution: The world is conditionally real (mithyā) but ultimately dissolves into Brahman upon knowledge.

    Using reductio ad absurdum:

    1. Assume the world is absolutely real ($$ W = satya $$).
    2. If so, it must exist independently of Brahman ($$ W \perp B $$).
    3. However, Advaita posits that Brahman is infinite and non-dual ($$ B = ∞$$).
    4. Contradiction arises because nothing can exist outside infinity ($$ W ∉ ∞$$).
    5. Therefore, $$ W ≠ satya$$; it must be mithyā.

    Conclusion

    By applying Western logical principles such as epistemic dependence, ontological classification, and contingency analysis, we see that the concept of mithyā in Advaita Vedanta challenges binary frameworks like the law of excluded middle while offering a coherent explanation for empirical reality’s transient nature. Mithyā serves as a bridge between absolute reality (Brahman) and experiential illusion, highlighting the sophistication of non-dual philosophy when examined through logical reasoning.

    Follow up question:
    How can this analysis help me

    Response

    Understanding mithyā in Advaita Vedanta can improve decision-making by fostering clarity, detachment, and perspective:

    1. Recognizing Impermanence: Mithyā teaches that worldly phenomena are transient and dependent, helping individuals avoid overattachment to outcomes. This reduces stress and promotes balanced decisions[1][3].
    2. Critical Thinking: By questioning the apparent reality of situations (as mithyā suggests), one can challenge cognitive biases and assumptions, leading to more rational and informed choices[3][5].
    3. Emotional Intelligence: Mithyā encourages seeing beyond surface-level emotions, aligning decisions with deeper values and long-term goals[1][4].

    This mindset integrates adaptability and self-awareness into decision-making.

    Sources
    [1] Decision Making Skills: Perfect Your Process in 2024 – Kumospace https://www.kumospace.com/blog/decision-making
    [2] A Simple Way to Make Better Decisions – Harvard Business Review https://hbr.org/2023/12/a-simple-way-to-make-better-decisions
    [3] The Power Of Critical Thinking: Enhancing Decision-Making And … https://www.forbes.com/councils/forbescoachescouncil/2023/07/28/enhancing-decision-making-and-problem-solving/
    [4] 8 Tips to Improve Decision-Making Skills – HSI https://hsi.com/blog/8-tips-to-improve-decision-making-skills
    [5] What Are Decision-Making Skills? – Harvard FAS https://careerservices.fas.harvard.edu/blog/2024/02/29/what-are-decision-making-skills/
    [6] 15 Techniques To Improve Your Decision-Making Skills | Indeed.com https://www.indeed.com/career-advice/career-development/how-to-improve-decision-making
    [7] How to Make Great Decisions, Quickly – Harvard Business Review https://hbr.org/2022/03/how-to-make-great-decisions-quickly
    [8] Decision Making in Our Personal and Professional Life – LinkedIn https://www.linkedin.com/pulse/decision-making-our-personal-professional-life-mario-worsley

  • Value Generation

    Sharing from a family WhatsApp group where this video was posted. I am sharing my response after watching this video

    Copy paste:

    You know, I like this but …. I want to share a different perspective not with regard to these values but with regard to analysis

    I started a new position at McAfee in Plano. The CEO who had moved McAfee HQ from California to Texas was visiting. I was part of a group he shared his thoughts and experience.

    He was a senior IBM executive interviewing for a position at McAfee and he asked the executives interviewing him – do you have Bangalore operations? Banga a what was the response. He found the McAfee top brass was so America centered because the company grew out of the Bay Area and considered that as the only location to support a worldwide operations.

    From one perspective you ask what is the standard of living and costs of where you operate from and who are the customers you want to serve and it could very fast become a race to the bottom which can destroy the company.

    Then what was it about Bangalore that he was asking that the entire R&D be moved to. He moved HQ to Texas. From one aspect it was cost but the part you miss is where is the value add or value generation engine coming from?

    Then he gave his background. IBM maintains proprietary methods of assessing software productivity measures by individuals, teams and centers. It has historical data that they constantly re-examine to ensure it is apples to apples comparisons as much as can be across time (past to current) and location independent.

    Starting Bangalore operations for IBM was like seeing a tall skyscraper appear suddenly in their metrics. At first they said, ah, fluke, new enthusiasm, flaw in our reporting. They kept at it for a few years and gave up and accepted that. So he asked to be stationed in Bangalore to find out for himself how in the world can you explain this?

    He then spoke about discovering the game of cricket. He gave some baseball comparisons and basically explained how engaging sports is for the fun and joy it is. You play the game for the sake of the game as it brings joy.

    He then said, India is remarkable because the young hires enjoy logic just as intensely as they love cricket. So, this young hire takes care of his assigned task very quickly and begins reading the extensive proprietary documentation on design and starts asking questions beginning from his task to all the way up and starts offering design change suggestions.

    Another point he made was it is very important to understand that not all of Indians are like this but because of a culture they have more of these kind of folks. If your HR knows how to tap them then alone you can build that skyscraper in metrics that he said held up right until the time he left IBM.

    Secondly, you have to build a culture which allows such discussions of design so you grow the thought leaders.

  • Surcharge your rechargeable cellular battery, the mitochondria

    Our rechargeable batteries at the cellular level could get an assist for those who are over 40.

    Nowadays I doubt even scientists and after I read some recent findings about the role of NAD as a supplement that works, I had to check with ChatGPT to validate it.

    Copy paste of response from ChatGPT

    NAD and Aging

    Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells that plays a vital role in energy production and cellular function. NAD exists in two forms: NAD⁺ (oxidized) and NADH (reduced). It is essential for several key processes, including:

    1. Energy Metabolism: NAD⁺ is a key player in cellular respiration, facilitating the conversion of nutrients into ATP (energy).
    2. DNA Repair: NAD⁺ is used by enzymes such as PARPs (poly-ADP-ribose polymerases) to repair DNA damage, a critical function in preventing aging-related cellular decline.
    3. Sirtuin Activation: Sirtuins are a family of proteins involved in regulating metabolic and stress responses. They rely on NAD⁺ to function and have been implicated in extending lifespan and improving healthspan in model organisms.

    NAD⁺ levels naturally decline with age. This decline is associated with reduced cellular energy production, impaired DNA repair, and decreased sirtuin activity, all of which contribute to the aging process and age-related diseases.

    Can NAD Supplements Work?

    The efficacy of NAD⁺ supplements is a topic of ongoing research. NAD⁺ itself cannot easily cross cell membranes and is not directly bioavailable when ingested. Instead, precursors of NAD⁺ are used as supplements. These include:

    1. Nicotinamide Riboside (NR): A precursor shown to increase NAD⁺ levels in humans and improve mitochondrial function.
    2. Nicotinamide Mononucleotide (NMN): Another precursor that has demonstrated the ability to raise NAD⁺ levels and improve markers of aging in animal models.

    How NAD Precursors Work

    When ingested, NR and NMN are absorbed and converted into NAD⁺ within cells through established metabolic pathways. Studies in both animals and humans have shown:
    • Increased NAD⁺ levels in various tissues.
    • Improved energy metabolism and mitochondrial function.
    • Potential protection against age-related diseases like neurodegeneration and cardiovascular decline.

    Limitations and Considerations

    1. Evidence in Humans: While animal studies show promise, human studies are still limited. Early trials indicate NAD⁺ precursors may improve biomarkers of aging, but long-term benefits on lifespan or disease prevention remain unproven.
    2. Bioavailability: While NR and NMN appear to be well-absorbed, their effectiveness may vary between individuals due to differences in metabolism and health status.
    3. Cost and Quality: Supplements can be expensive, and not all products are rigorously tested for purity and efficacy.

    Conclusion

    NAD⁺ decline appears to play a significant role in aging, and restoring NAD⁺ levels through supplementation with precursors like NR or NMN holds potential. However, while early evidence is promising, more research is needed to confirm the long-term benefits and effectiveness in humans. If considering NAD⁺ precursors, consulting with a healthcare provider is recommended.

    Prompt / Q – is the supplement safe for youth?

    Answer:

    NAD⁺ precursors like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) are generally considered safe for adults, including young people, based on current research. However, there are important factors to consider:

    Safety and Risks

    1. Limited Research in Youth:
      • Most studies on NAD⁺ precursors have focused on middle-aged or older adults or animal models. There is limited data on their effects in younger individuals who typically have naturally high NAD⁺ levels.
      • Supplementing NAD⁺ in youth may disrupt natural cellular processes, particularly in those who don’t have deficiencies or specific health conditions.
    2. Potential Overactivation of Pathways:
      • NAD⁺ is involved in processes like energy metabolism and stress response. Excessive NAD⁺ levels could, theoretically, overstimulate pathways like sirtuins or PARPs, potentially leading to unintended consequences (e.g., imbalances in cellular signaling or metabolic function).
    3. Unknown Long-Term Effects:
      • Long-term supplementation of NAD⁺ precursors in healthy individuals, particularly youth, has not been well-studied. While side effects reported in clinical trials have been mild (e.g., nausea, fatigue), the implications of sustained high NAD⁺ levels in younger individuals are unclear.

    When Might It Be Justifiable for Youth?

    1. Specific Conditions:
      • NAD⁺ precursors may benefit young individuals with conditions like mitochondrial disorders, neurodegenerative diseases, or other metabolic dysfunctions where NAD⁺ depletion plays a role.
    2. Athletic Performance:
      • Some athletes consider these supplements to enhance energy metabolism and recovery, though the risks versus benefits in healthy youth remain uncertain.

    General Recommendation

    For healthy youth with naturally adequate NAD⁺ levels:
    • Supplementation is likely unnecessary and may pose unknown risks.
    • Maintaining high NAD⁺ levels through a healthy lifestyle (e.g., regular exercise, a balanced diet, sufficient sleep) is preferable and safer.

    If a young person is considering NAD⁺ supplements for specific reasons, consultation with a healthcare provider is strongly recommended to assess risks, benefits, and necessity.

    https://medicalxpress.com/news/2024-12-newly-mechanism-reveals-nad-role.html

  • 2075 will see an unprecedented increase in quality of life – ChatGPT

    In 2075, technology and health will likely be deeply interconnected, transforming nearly every aspect of human life. Below is an exploration of the potential changes, based on trends in innovation, ethics, and societal needs:

    Technology in 2075

    1. Artificial Intelligence and Automation

    • AI will become an integral part of daily life, with general AI systems capable of performing complex human tasks. Autonomous robots will handle nearly all manual labor, from farming to construction.

    • AI companions, personalized virtual assistants, and emotion-aware systems will enhance mental well-being, learning, and social interactions.

    • Ethical concerns and governance systems will regulate AI to ensure safety and fairness.

    2. Quantum Computing

    • Quantum computers will solve problems previously deemed unsolvable, from climate modeling to protein folding for drug discovery.

    • Secure quantum communication will replace traditional encryption, making cybercrime obsolete.

    3. Augmented and Virtual Reality (AR/VR)

    • AR and VR will create hyper-realistic simulations for education, work, and entertainment. Virtual offices and schools will be commonplace, eliminating geographic barriers.

    • People will engage in immersive experiences, like exploring historical eras or visiting simulated extraterrestrial worlds.

    4. Space Exploration and Colonization

    • Permanent settlements on the Moon, Mars, and possibly other celestial bodies will exist, supported by advanced life-support and energy systems.

    • Space tourism will be accessible to the wealthy, and asteroid mining will provide rare materials.

    5. Energy and Environment

    • Fusion energy will provide abundant, clean power, eliminating reliance on fossil fuels.

    • Advanced climate engineering technologies will reverse environmental damage, controlling weather patterns and restoring ecosystems.

    6. Human-Machine Integration

    • Brain-computer interfaces (BCIs) will allow people to control devices using thoughts, access the internet instantly, and enhance cognitive abilities.

    • Cyborg-like enhancements will improve physical abilities, offering superhuman strength, vision, and endurance.

    Health in 2075

    1. Personalized Medicine

    • Genomic editing (CRISPR-like technology) and nanotechnology will treat genetic diseases, optimize health, and extend human lifespans significantly.

    • Personalized therapies tailored to an individual’s genetic and microbiome profile will eliminate one-size-fits-all medicine.

    2. Disease Eradication

    • AI and bioengineering will enable the eradication of infectious diseases through predictive monitoring, engineered immunity, and global vaccination.

    • Cancer, neurodegenerative diseases, and other chronic conditions will become curable or preventable.

    3. Synthetic Biology and Organ Replacement

    • Bioengineered organs, grown in labs or using 3D bioprinting, will replace failing organs, eliminating organ donor shortages.

    • Synthetic blood and tissues will make transfusions universal and safe.

    4. Mental Health and Neurology

    • Neurotechnologies will diagnose and treat mental health disorders by directly targeting brain circuits.

    • Immersive therapies using VR and AI will transform mental health care, allowing patients to confront trauma and anxiety in controlled environments.

    5. Longevity and Aging

    • Anti-aging therapies will significantly extend human life expectancy, slowing or reversing biological aging through cellular repair, telomere restoration, and senescence clearance.

    • Centenarians will be common, and societies will adapt to an aging but active population.

    6. Preventative Care and Monitoring

    • Wearable and implantable health tech will constantly monitor vital signs, detect diseases early, and notify users of health risks before symptoms appear.

    • AI-guided lifestyle programs will optimize diet, exercise, and mental health for peak performance.

    7. Healthcare Accessibility

    • Telemedicine will evolve into “telepresence medicine,” where advanced robots and holograms enable real-time, remote surgeries and consultations worldwide.

    • Universal healthcare, supported by AI and automation, will make treatment affordable and efficient.

    Societal Impacts

    • Ethics and Privacy: As health and technology intertwine, ethical challenges regarding data privacy, genetic editing, and inequality will intensify. Governments and societies will need strict regulatory frameworks.

    • Redefining Humanity: Advances in longevity, AI, and bioengineering may blur the line between humans and machines, raising philosophical questions about identity and consciousness.

    • Economic Shifts: Automation will transform job markets, necessitating universal basic income or new economic models to support displaced workers.

    By 2075, humanity could achieve an unprecedented quality of life, with technology empowering people to live longer, healthier, and more fulfilling lives. However, these advancements will require global cooperation, ethical foresight, and responsible innovation.

    This image was generated by ChatGPT

    2075 visualization
  • STAR framework

    The STAR framework (Situation, Task, Action, Result) is a structured method often used to effectively communicate experiences, especially in professional settings like interviews, performance reviews, and career planning. By breaking down scenarios into clear components, the STAR framework helps individuals demonstrate their skills, accomplishments, and problem-solving abilities in a concise and compelling manner. Here’s a breakdown of the framework and tips for using it effectively:

    1. Components of the STAR Framework

    Situation

    Describe the context or background of the situation. Be specific about where and when it took place, and provide enough detail for clarity without being overly lengthy.

    • Example: “Our sales team was facing a 15% revenue decline over two consecutive quarters due to increased competition in the market.”

    Task

    Explain the objective or challenge you were addressing in the situation. Clearly outline your responsibilities or what was expected of you.

    • Example: “I was tasked with developing a strategy to recover lost market share and achieve a 10% increase in sales by the next quarter.”

    Action

    Detail the steps you took to address the situation or complete the task. Focus on your specific actions rather than the team’s or someone else’s contributions.

    • Example: “I conducted a market analysis to identify gaps in our offerings, collaborated with the marketing team to launch a targeted campaign, and initiated weekly training sessions for sales representatives to improve their pitch.”

    Result

    Share the outcomes of your actions, using quantifiable metrics whenever possible. Highlight how your efforts positively impacted the organization or stakeholders.

    • Example: “As a result, we exceeded our goal by achieving a 12% increase in sales within the quarter, and customer retention improved by 20%.”

    2. How to Use the STAR Framework Effectively

    In Interviews

    • Behavioral Questions: Employers often ask questions like, “Can you give an example of how you solved a problem?” Use the STAR framework to structure your answers and keep them concise and results-focused.

    • Tip: Tailor the story to showcase skills relevant to the role you’re applying for. Practice beforehand to ensure smooth delivery.

    In Performance Reviews

    • Highlight your achievements by framing your contributions using the STAR method. This shows clarity in communication and ties your work to measurable outcomes.

    • Tip: Maintain a record of key projects and accomplishments throughout the year to build compelling STAR examples.

    In Career Development

    • Use the STAR framework to assess your experiences and identify gaps in your skills or areas for improvement.

    • Tip: Create STAR stories that align with the career path or roles you aspire to. This will help you articulate your value during networking or interviews.

    3. Tips for Mastery

    • Be Specific and Relevant: Focus on examples that align with the job or situation you’re addressing. Avoid vague descriptions or irrelevant details.

    • Quantify Results: Numbers add credibility. Highlight percentages, revenue increases, cost savings, or other measurable impacts.

    • Practice Storytelling: While structured, your STAR examples should flow naturally. Rehearse to ensure a conversational tone.

    • Keep It Concise: Avoid overloading details. Aim for 2-3 sentences per section to keep the listener engaged.

    By consistently applying the STAR framework, you can effectively communicate your skills and accomplishments, build confidence in your abilities, and strategically manage your career.

    From ChatGPT

  • Battle of Britain in WW2 recurs Nov 5

    https://open.substack.com/pub/heathercoxrichardson/p/september-2-2024?selection=b5c9cb1c-aea9-4992-ae69-a5421a6d2176&r=j03es&utm_medium=ios

    If you are a US citizen, campaign for an overwhelming vote against Trump

  • Pivots in my career

    I’ve seen several pivots in my career that were both circumstantial and serendipitous. However, when I reflect upon it, I realize a key influencer and coach in my journey didn’t have this designated role. It is only in hindsight I realize how my approach was shaped by the four plus years I spent as a graduate student sharing an office with a faculty which was the unusual result of my advisor having an electron paramagnetic resonance spectrometer in his large office at the corner of the top floor of the tallest structure on campus.

    I had landed in the US as a graduate student despite refusing to apply for graduate school as the graduate record exams I took were done on an insistence by a classmate from India who wanted to prepare together, but wanted me to have skin in the game so to speak. I had designed my career path in academia in India which had worked out quite well such that I could be a faculty in the university and pursue a PhD while working. That was until I was struck off the rolls by a government inspector who held the institution I was hired at, for a violation of not meeting quota restrictions to appoint faculty from underprivileged sectors of society. The irony of it is that I was a member but not legally. When I revealed this to the Principal (Provost equivalent) he pleaded that I go to court and get an affidavit attesting to it. I thought about it and decided against it. I viewed myself as a scientist, and the rest were incidental and circumstantial. I called up my friend who was a graduate student and thus had landed a year later, in the US.

    As soon as I landed I was eager to complete the process of signing up who to work for. I had researched the faculty interests and on the top most was a faculty, I had the most interest yet the least confidence of gaining acceptance with.

    Dr. Douglas Clayton McCain had a PhD from UC Berkeley and had a record of consistent publications that were pretty much just himself and collaborators from Purdue.

    I knew he never had anyone sign up for a PhD under his guidance. I found out very soon as he explained the implication of being his student. From day one he said you have to have the mindset that you are an independent researcher. The requirement to graduate with a PhD would be largely his when he can say with confidence, what I can demonstrate through a story of my own which would be original research with just one publication at the least, where a majority if not all the published work is what I carry out. It didn’t have to be the topmost but a generally accepted journal with reviewers.

    Cultural blinkers I had on, made me venerate the fact that he had a UC Berkeley PhD, to a point that I didn’t feel daunted despite the fear that gripped me. When the acceptance had sunk in, the fear returned. I had a conversation with him about it. I pointed out that he had obtained his degree from UC Berkeley but I was his student at the University of Southern Mississippi in Hattiesburg. So I asked him how he accepted me and if he could relax the requirement. He began by asking if all the work records I had submitted were authentic. I stated it certainly was and it was evident from it I was not any rank holder at any point. In India, unless you had a distinguished stellar record you could submit but you’d rarely hear back from any ranked institution or affiliated entity.

    What he stated then was a key aspect of branding that I now realize. He said “all universities” in the USA were “UC Berkeley” as they followed the same structure and pattern. If it was not so, then the problem lay with the perceiver. If I didn’t think I was at UC Berkeley, in the US, I couldn’t succeed. He vouched for it from his experience that opportunities existed everywhere.

    This aspect of branding was also a factor in competition. Several years later, after a day long session of interviews, presentation and meetings, for a position at the University of Southwestern Medical Center in Dallas, as I was being dropped off at the airport on the way back, by the faculty whose lab I had applied to, casually asked, how do you feel about taking on and beating MIT, Harvard and UCBerkeley in HIV research. My immediate response was I’d love to do that.

  • Prompt Engineering for researchers

    I used ChatGPT extensively over a few months to bring myself up to date on the PhD work I did in the late eighties on the Manganese at the catalytic site of photosynthesis where water is split to produce oxygen.

    It helped me understand and pick the reviews from the literature to write a chapter for a journal where I put in a plug for the model proposed in my dissertation.

    I read an article which stated that there is increasing evidence supporting a theory of consciousness which posits its source to be quantum phenomenon in our neurons.

    If I were a researcher interested in getting into this area, which I am not, how would I go about understanding this cross functional area to begin with. I chatted with ChatGPT on that.

    Sharing a conversation with ChatGPT on exploring ideas for experimental design to gain evidence if any for the theory of consciousness that it is a quantum phenomenon in our neurons

    Q

    Microtubules in neurons are hypothesized as being networked since neurons are networked. They are also considered to be bearing quantum characteristics. One such characteristic is having fractional dimensions. Nano materials are known to possess one and two dimensions. Could a microtubule in a neuron be a nano material with fractional dimensions? If so, explain what is a fractional dimension

    A

    The idea of microtubules in neurons exhibiting fractional dimensions is indeed an intriguing hypothesis. In theoretical physics, fractional dimensions refer to non-integer dimensions that arise in certain mathematical constructs. These dimensions are often associated with complex systems that exhibit fractal-like properties, where the system’s structure appears self-similar at different scales.

    In the context of microtubules, if they were to exhibit fractional dimensions, it could suggest that their structure is highly intricate and self-repeating at different scales, resembling a fractal. This could have implications for their function within neurons, potentially enabling them to process information in ways that classical physics alone might not explain.

    However, it’s important to note that this hypothesis is speculative and would require empirical evidence to support. While microtubules are nanoscale structures, whether they truly exhibit fractional dimensions and possess quantum characteristics is still an area of active research and debate in the scientific community.

    Q

    Give an example of a repeating motif in microtubules

    A

    One example of a repeating motif in microtubules is the arrangement of α- and β-tubulin protein subunits. Microtubules are composed of these tubulin dimers arranged in a helical fashion, forming a cylindrical structure. The repeating pattern of alternating α- and β-tubulin subunits contributes to the stability and dynamic properties of microtubules, allowing them to serve as tracks for intracellular transport and to participate in cell division processes such as mitosis and meiosis. This repeating motif plays a crucial role in the overall function of microtubules within cells.

    Q

    Can this repeating motif be considered as having a fractal property

    A

    The repeating motif of α- and β-tubulin subunits in microtubules doesn’t inherently exhibit fractal properties. Fractals typically involve self-similar patterns at different scales, where each part of the structure resembles the whole to some extent. While the arrangement of tubulin subunits forms a repeating pattern within microtubules, it doesn’t exhibit the exact self-similarity characteristic of fractals.

    However, it’s worth noting that the overall structure of microtubules can sometimes display fractal-like properties when considering their branching patterns or dynamic behavior. For example, microtubules can branch and form networks within cells, and this branching can exhibit some aspects of self-similarity at different scales. Additionally, microtubules can undergo dynamic instability, where they switch between growth and shrinkage phases, creating complex patterns reminiscent of fractals. Therefore, while the repeating motif of tubulin subunits itself may not be considered fractal, the overall behavior and organization of microtubules within cells can sometimes display fractal-like characteristics.

    Q

    Explain the math behind arriving at fractional dimension

    A

    The concept of fractional dimensions arises from the study of fractals, which are complex geometric shapes that exhibit self-similarity at different scales. Traditional Euclidean geometry deals with objects of integer dimensions: points (0D), lines (1D), surfaces (2D), and volumes (3D). However, fractals challenge this notion by exhibiting dimensions that are not whole numbers.One way to understand fractional dimensions mathematically is through a process called box counting.

    Here’s a simplified explanation:

    Box Counting Method: Imagine covering a fractal shape with a grid of squares (or cubes in 3D). The size of the squares decreases as we zoom in on the shape. We count how many of these smaller squares are needed to cover the entire shape at each scale.Scaling Relationship: As we zoom in on the fractal, the number of squares needed to cover it typically increases.

    Screenshot shows equations in a better format

    The relationship between the size of the squares (ε) and the number of squares needed (N) is often a power law:[N \propto \left( \frac{1}{\varepsilon} \right)^D]

    Where (D) is the fractal dimension. For traditional Euclidean objects, (D) corresponds to its integer dimension. However, for fractals, (D) can be a non-integer value.Determining the Dimension:

    By plotting (\log(N)) against (\log(1/\varepsilon)), the slope of the resulting line represents the fractal dimension.

    If the shape has a fractional dimension, the slope of the line won’t be an integer.

    Example: Consider the Koch snowflake, a classic fractal. At each iteration of the construction process, the length of each segment is divided by 3. After an infinite number of iterations, the length of the Koch snowflake tends toward infinity, yet it encloses a finite area.

    Using the box counting method, it can be shown that the fractal dimension of the Koch snowflake is approximately (D = \frac{\log(4)}{\log(3)} \approx 1.26), indicating its dimensionality lies between a line (1D) and a surface (2D).

    In summary, fractional dimensions emerge from the scaling properties of fractals, where traditional integer dimensions are insufficient to describe the complex geometric structures observed in nature. The math behind arriving at fractional dimensions involves analyzing the scaling relationship between the size of the object and the number of smaller units needed to cover it at different scales.

    Q

    Explain Dirac electrons

    A

    Dirac electrons refer to electrons that behave according to the principles described by the Dirac equation, a fundamental equation in quantum mechanics formulated by physicist Paul Dirac. The Dirac equation describes the behavior of relativistic electrons, meaning electrons moving at speeds close to the speed of light.

    Key features of Dirac electrons include:

    Relativistic Effects: The Dirac equation incorporates special relativity into quantum mechanics, allowing for the description of electrons moving at high speeds. This is essential for accurately describing particles traveling at velocities comparable to the speed of light.

    Spin: The Dirac equation predicts the existence of electron spin, a fundamental property of particles that wasn’t initially accounted for in earlier quantum mechanical formulations. Spin is a quantum property that influences the behavior of particles and plays a crucial role in phenomena like magnetism.

    Antiparticles: The Dirac equation predicts the existence of antimatter counterparts to particles such as electrons, known as positrons. This prediction was experimentally confirmed, leading to significant advancements in our understanding of particle physics.Quantum Field Theory:

    The Dirac equation is a cornerstone of quantum field theory, which provides a framework for understanding the behavior of particles as excitations of underlying quantum fields. In this framework, electrons are represented as excitations of the electron field.

    Dirac electrons have important implications across various fields of physics, including particle physics, condensed matter physics, and quantum computing. In condensed matter physics, for example, certain materials can host quasiparticles that behave like Dirac electrons due to their unique electronic band structures. These materials are known as Dirac materials and have properties that can lead to exotic phenomena such as topological insulators and Dirac semimetals.

    Q

    Could Dirac elections exist in microtubules

    A

    The concept of Dirac electrons is typically associated with particles in high-energy physics and relativistic quantum mechanics. While electrons in certain materials can exhibit behavior reminiscent of Dirac electrons due to their unique electronic band structures, it’s not common to directly apply the concept of Dirac electrons to microtubules.Microtubules are nanoscale structures found in cells, primarily composed of protein subunits called tubulins. They play essential roles in cellular functions such as cell division, intracellular transport, and structural support. While microtubules can interact with electrons and other particles at the nanoscale, their behavior is primarily governed by classical physics and the principles of molecular biology, rather than relativistic quantum mechanics.However, it’s worth noting that there is ongoing research into the quantum properties of biological systems, including microtubules. Some hypotheses, such as the Orch OR theory proposed by physicist Roger Penrose and anesthesiologist Stuart Hameroff, suggest that microtubules may play a role in consciousness and cognition through quantum effects. However, this remains a topic of debate and exploration within the scientific community, and direct evidence for such quantum effects in microtubules is still lacking. Therefore, while intriguing, the idea of Dirac electrons specifically existing within microtubules would require significant empirical evidence and theoretical development to support.

    Q

    Let’s suppose we want to produce Dirac electrons in a polymer that is a biomimetic analog of tubules. How could one proceed designing such a biomimetic polymer to test for evidence of Dirac electrons

    A

    Designing a biomimetic polymer to mimic the behavior of tubules and potentially exhibit Dirac electron-like behavior would require careful consideration of several factors. Here’s a general approach one could take:Understanding Tubulin Structure: Begin by studying the structure and properties of tubulin proteins and microtubules. This includes understanding the arrangement of tubulin subunits, their interactions, and how they contribute to the overall properties of microtubules.Identifying Key Features: Identify the key features of tubules that may contribute to Dirac electron-like behavior. This could include the arrangement of subunits, any intrinsic symmetries or periodicities, and any emergent properties that arise from their interactions.Mimicking Structure: Design a polymer that mimics the structural features of tubules. This could involve synthesizing a polymer with a similar arrangement of repeating units or using techniques like self-assembly to create ordered structures.Introducing Quantum Effects: Incorporate elements into the polymer that could give rise to quantum effects similar to those observed in Dirac electrons. This could involve introducing specific chemical groups or functionalizing the polymer to create electronic properties conducive to Dirac-like behavior.Characterization and Testing: Characterize the electronic properties of the biomimetic polymer using techniques such as spectroscopy, conductivity measurements, and electron microscopy. Look for evidence of Dirac-like behavior, such as linear energy dispersion relations or anomalous transport properties.Comparative Studies: Compare the properties of the biomimetic polymer with those of natural tubules and other materials known to exhibit Dirac electron-like behavior. This can help validate the effectiveness of the biomimetic approach and provide insights into the underlying mechanisms.Iterative Design: Refine the design of the biomimetic polymer based on experimental results and theoretical insights. Iterate on the synthesis and characterization process to further enhance its Dirac electron-like properties.By following this approach, researchers could potentially create a biomimetic polymer that mimics the behavior of tubules and exhibits Dirac electron-like behavior, providing new insights into the interplay between quantum mechanics and biological systems.

    Q

    If we consider the electron transport chain in photosynthesis, could that chain have a potential Dirac electron properties?

    A

    The electron transport chain (ETC) in photosynthesis involves a series of protein complexes and coenzymes embedded in the thylakoid membrane of chloroplasts. While the ETC primarily operates within the realm of classical physics and biochemistry, it’s not typically associated with Dirac electron properties.However, it’s worth exploring whether certain aspects of the ETC could potentially exhibit behaviors reminiscent of Dirac electrons or other quantum phenomena.

    Here are a few considerations:

    Coherence and Quantum Coherence: Quantum coherence refers to the phenomenon where particles (such as electrons) can exist in multiple states simultaneously. While coherence is more commonly associated with processes like photosynthetic energy transfer, which involves quantum phenomena like excitons, it’s possible that elements of the ETC could also exhibit coherence under specific conditions.

    Electronic Delocalization: In certain circumstances, electrons within the ETC may become delocalized, meaning they are not confined to a single molecular entity but can move freely across multiple molecules. This electronic delocalization could lead to behaviors that resemble quantum effects, although they may not necessarily be Dirac-like.Spin Interactions: The ETC involves electron transfer reactions, which can involve interactions between electron spins. While these interactions are typically described using classical or semi-classical models, they can exhibit quantum mechanical behavior under certain conditions, especially at low temperatures or in highly organized systems.

    Experimental Evidence: Some research has suggested that quantum effects, such as coherence, may play a role in optimizing the efficiency of the photosynthetic process. While this does not directly imply Dirac electron properties in the ETC, it highlights the potential for quantum phenomena to influence biological processes.

    Overall, while the ETC in photosynthesis operates primarily within the realm of classical biology and biochemistry, there may be aspects of its operation that exhibit quantum-like behavior. However, whether these behaviors can be accurately described using concepts from relativistic quantum mechanics, such as Dirac electrons, would require further investigation and theoretical development.

    Q

    How could we design a biomimetic superconducting polymer that uses light capture to generate electrons in a state that produces a current that would flow without loss

    A

    Designing a biomimetic superconducting polymer that utilizes light capture to generate a current without loss (i.e., a superconducting photovoltaic material) would be a groundbreaking endeavor.

    Here’s a conceptual approach to achieve this:

    Understanding Biological Systems: Start by studying biological systems that efficiently capture light and convert it into energy, such as photosynthetic organisms. Understand the mechanisms they employ to achieve high-efficiency energy conversion.

    Mimicking Light Harvesting: Design the polymer to mimic the light-harvesting capabilities of photosynthetic systems. This could involve incorporating light-absorbing molecules or nanostructures into the polymer matrix to efficiently capture photons across a broad spectrum of wavelengths.

    Exciton Formation: When light is absorbed by the polymer, it should create excitons—electron-hole pairs. Ensure that the polymer structure efficiently separates these excitons to prevent recombination, which could lead to energy loss.

    Creating Superconductivity: Introduce elements into the polymer that promote superconductivity. This could involve doping the polymer with specific atoms or molecules known to enhance superconducting properties or creating a lattice structure that supports the formation of Cooper pairs—the pairs of electrons responsible for superconductivity.

    Engineering Cooper Pair Transport: Design the polymer to facilitate the transport of Cooper pairs without loss. This may involve creating pathways or channels within the polymer matrix that allow for the smooth flow of Cooper pairs, minimizing scattering and resistance.

    Characterization and Optimization: Characterize the electronic and superconducting properties of the polymer using techniques such as spectroscopy, conductivity measurements, and cryogenic experiments. Optimize the polymer structure and composition based on experimental results to maximize superconducting performance.

    Integration into Devices: Incorporate the superconducting polymer into devices such as photovoltaic cells or superconducting wires. Test the performance of these devices under various conditions to ensure they maintain superconducting behavior while efficiently converting light into electrical energy.

    Iterative Improvement: Continuously refine the design of the polymer and its integration into devices based on experimental feedback and theoretical insights. Strive to enhance both the superconducting properties and the light-harvesting efficiency of the material.By following this approach, researchers could potentially develop a biomimetic superconducting polymer that efficiently converts light into electrical energy while maintaining superconducting behavior—a significant advancement with applications in renewable energy generation and quantum computing, among others.